Archangel Gabriel and his three mischievous Prayer Ambassadors--Shirley, Goodness and Mercy--lend their celestial aid to three needy Christmas cases. Harry Alderwood, 86, prays that his increasingly forgetful wife, Rosalie, will agree to move into assisted living before he dies. Meanwhile, nine-year-old Carter Jackson begs God for a dog, even though his mother and father tell him that they can't afford to keep a pet, while Beth Fischer's mother prays...

Isabella falls for Nick Hartley after he rescues her from a car accident, but he is too busy reconnecting with his estranged teenaged daughter to admit an attraction. Meanwhile, Isabella's police chief brother is working on a case involving a missing mother, an abandoned baby, and an unknown father.