With an asteroid on a collision course with Earth, Doctor Toby Glyer and his partner William Connors must find a way to make contact with their wayward children -- the Briareus nanites -- and save the planet.

Two years after they saw him die, the man they knew as Victor Helios lives on. Detectives Carson O'Connor and Michael Maddison; Victor's engineered wife, Erika 5, and her companion Jocko; and the original Victor's first creation, the tormented Deucalion, have all arrived at a small Montana town where their old alliance will be renewed--and tested--by forces from within and without, and where the dangers they face will eclipse any they have yet encountered....

Weapons expert James McCullen has created a nanotechnology-based weapon capable of destroying an entire city. His company MARS sells four warheads to NATO, and the U.S. Army is tasked with delivering the warheads. Duke and Ripcord are delivering the warheads when they are ambushed by the Baroness. The two are rescued by Scarlett, Snake Eyes and Heavy Duty. They take the warheads to the G.I. Joe's command center, rendezvousing with General Hawk. McCullen...

An elite military unit comprised of special operatives known as G.I. Joe, operating out of The Pit, takes on an evil organization led by a notorious arms dealer.